nonlinear regression and nonlinear least squares in R

a useful document

http://socserv.mcmaster.ca/jfox/Books/Companion/appendix/Appendix-Nonlinear-Regression.pdf

CV values

noise level test: bigger CV value means more noisy data
higher G (shape) parameter in model simulation reveals smaller lifespan data values.
higher R(rate) parameter in model simulation reveals higher mean lifespans.

free hard drive space command

df -H : hard drive allocation and usage check
top     : memory usage check (slow method)
vm_stat : memory usage check (faster)

Academic writing tips

Ten easy rules from Zhang et al:

http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003453#pcbi.1003453-Watson1

today's note

1)Copy number variation. CNV is worth to study. : http://www.nature.com/scitable/topicpage/copy-number-variation-445
2)Focus C. elegans for next project as experimental lifespan data sets.
3)Data bases for lifespan :

http://kaeberleinlab.org/projects/lifespan-observations-database

*Observations database
*Sagaweb database
*Managed databases

solving ODEs

A nice recalling examples here:

http://mathinsight.org/ordinary_differential_equation_introduction

Bayesian statistics vs Maximum Likelihood estimation

Screenshot is taken from Hartig et.al 2011, Statistical inference for stochastic simulation models – theory and application

 

here is description why we are normalizing the posterior position in Bayesian statistics.